is reconstitution solution the same as bacteriostatic water?

As discussed earlier, peptide mixing water is used to dissolve/dilute the lyophilized peptides. Bacteriostatic Water for Injections | The A-Z Guide The second step is to use your syringe and draw out 1ml of bacteriostatic water from the vial without really touching the needle as it could cause contamination. For more information, please see our Two sterile solutions that are commonly used are bacteriostatic water and sterile water. Bacteriostatic water formulations for injection have pH levels of 4.5-7, averaging 5.7. You hereby indemnify to the fullest extent Buckle LLC from and against any and/or all liabilities, costs, demands, causes of action, damages and expenses arising in any way related to your breach of any of the provisions of these Terms. So, the former is available in multi-dose containers that are viable for up to 28 days after opening, while sterile water comes in single-dose vials. Additionally, stability data should include provisions for the assay of aged samples and subsequent reconstitution of these aged samples for the maximum amount of time specified in the labeling. Note that you should absolutely not stir or shake the vial as it is going to damage the peptide and it will no longer be effective. Once a vial of sterile water is open, it should be used completely at once or used once and discarded. 4 people found this helpful. Do NOT reuse the same saline syringe to flush VADs before and after medication administration. It is a copolymer of ethylene and propylene. All Right Reserved. For the reconstitution of HGH powder, bacteriostatic water is a great choice, as it preserves HGH solutions and efficiently dissolves lyophilized aggregates [16]. Wipe down all materials with an alcohol swab. All you have to do is add the desirable reconstituted peptides in 1 vial and then use the syringe to pull out the mixture so that you can administer it. Well, people have been mixing peptides in the same syringe and then administering them. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. While most of the peptides will be soluble in bacteriostatic water and sterile water, some really wont, and this will be depending on the polarity of the peptides. So, if you are someone who has seen the vials of both types of water, I am sure you can now understand why a bacteriostatic water vial contains considerable volume while a sterile water vial contains just a few milliliters. The .gov means its official.Federal government websites often end in .gov or .mil. ITG SUBJECT: LYOPHILIZATION OF PARENTERALS. Now here comes the crux of the article after talking about some of the major prerequisites of the peptide reconstitution process. Once the peptide is really made soluble in any of the relevant solutions, diluting it with bacteriostatic water or sterile water is recommended. New comments cannot be posted and votes cannot be cast. Bacteriostatic water is water with benzyl alcohol. Both may be used in the injection of peptides, hormones, and various medications, often reconstituted from lyophilized powder. Injections are best suited to fatty areas, such as the thigh or waist. Cookie Notice It is also not known whether Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. As the title suggestswhats the difference between bacteriostatic water and reconstitution solution? Drug class: Sterile irrigating solutions. For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. Bacteriostatic water is better when diluting any medication because it offers better solubility for the most part. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Bacteriostatic waters preservative content prevents contamination for multiple doses, while sterile water may be contaminated after one use. Allow the powder to naturally dissolve until the vial is transparent. Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. Selective Estrogen Receptor Modulator (SERM), Induction of Ovulation with CLOMIMED 50 (Clomiphene Citrate), Anemia in Cancer Patients: treatment with DECAMED 250 (Nandrolone Decanoate), PROVIMED 25 (Mesterolone) for the Treatment of Male Infertility. In the event these should occur, re-evaluate the patient and institute appropriate corrective measures. Adverse reactions are rare and can include fever, infection, and thrombosis. Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. It is simply water that has gone through purification and distillation processes for its safe use in various therapeutic contexts, namely injections, dilution, and irrigation. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. However, this method requires special equipment and expertise. Bacteriostatic water and sterile water can be used in intravenous, intramuscular and subcutaneous injections. Bacteriostatic water is usually the term given to a commercial preparation (made by Hospira, for example), whereas reconstitution solution is the term given by a smaller (usually underground) company that makes its own to sell. These are the primary similarities between bacteriostatic water and sterile water [5]: Here are the key differences between bacteriostatic water and sterile water [5]: Despite their similarities, bacteriostatic water and sterile water differ in a few key areas.